olainfarm_Neiromidin

NEIROMIDIN®

Product INN: Ipidacrinum

Deva: 20 mg tablets; 5 mg/ml solution for injection; 15 mg/ml solution for injection

Product ATC Code: N07AA

Product Description

Neiromidin® is a reversible cholinesterase inhibitor used in
- peripheral nervous system diseases, such as neuritis, polyneuritis, polyneuropathy, polyradiculoneuropathy, myasthenia and myasthenic syndrome of various etiology;
- bulbar palsy and paresis;
- Recovery period after organic CNS (Central Nervous System) lesions with motion disorders;
- Complex therapy of demyelinating disease;
- Memory disorders of different origins, such as Alzheimer's disease and other forms of dementia in elderly;
- Intestinal atony.

Product Mechanism of Action

Neiromidin® directly stimulates impulse transmission in the CNS and neuromuscular synapses by blocking membrane potassium channels. Neiromidin® enhances not only choline, but also adrenaline, serotonin, histamine and oxytocin effects on smooth muscle.

Neiromidin® main pharmacological effects:
- restores and stimulates neuromuscular transmission;
- restores impulse transmission in the peripheral nervous system due to blockade, caused by various factors, such as trauma, inflammation, local anaesthetics, some antibiotics and potassium chloride exposure, etc.
- enhances smooth muscle contractility affected by the all agonists, excluding potassium chloride;
- moderately and specifically stimulates CNS in combination with some sedative activity;
- improves memory.
There are no adequate studies on the product safety for children.

Dosage

Neiromidin® 20 mg tablets should be administered orally with a glass of water.
Neiromidin® 5 mg/mL and 15 mg/mL solution for injection should be administered intramuscularly or subcutaneously. Doses and duration of the treatment should be determined individually, according to the severity of the disease.

Neiromidin® 20 mg tablets
Peripheral nervous system diseases, myasthenia and myasthenic syndrome:
The recommended dose is 10 to 20 mg 1 - 3 times per day. The course of treatment is 1 - 2 months. If necessary, treatment may be repeated several times at intervals of 1- 2 month.
Memory disorders of different origins, such as Alzheimer's disease and other forms of dementia in elderly:
Doses and duration of the treatment should be determined individually. The maximum daily dose may be increased up to 200 mg. The treatment duration is from 1 month and up to 1 year.
Treatment and prophylaxis of intestinal atony:
The recommended dose is 20 mg 2 - 3 times daily. The course of treatment is 1 - 2 weeks.

Neiromidin® 5 mg/mL and 15 mg/mL solution for injection
Peripheral nervous system diseases, myasthenia and myasthenic syndrome:
The recommended dose is 5 to 15 mg (1 ampoule of Neiromidin® 5 mg/mL or 15 mg/mL solution for injection) 1-2 times a day, administered as a single intramuscular or subcutaneous injection. The course of treatment is 1 - 2 months. If necessary, treatment may be repeated several times at intervals of 1- 2 month.
Prevention of myasthenic crisis in case of severe neuromuscular transmission disorders:
15 – 30 mg (1 – 2 mL of Neiromidin® 15 mg/mL solution for injection) should be administered parenterally over a short period of time. Treatment should be continued with Neiromidin® 20 mg tablets at doses of 20 – 40 mg 5 to 6 times daily.
Memory disorders of different origins, such as Alzheimer's disease and other forms of dementia in elderly:
Doses and duration of the treatment should be determined individually. The maximum daily dose may be increased up to 200 mg. The treatment duration is from 1 month and up to 1 year.

Attachments

Before use, carefully read the instructions. Consult your doctor or pharmacist about the use of medicines.
Medicines unreasonable use is harmful to health.